Protein engineering tests of a homology model of Plasmodium falciparum lactate dehydrogenase
نویسندگان
چکیده
منابع مشابه
DNA Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium vivax and Plasmodium falciparum Isolates
BACKGROUND Parasite lactate dehydrogenase (pLDH) is extensively employed as malaria rapid diagnostic tests (RDTs). Moreover, it is a well-known drug target candidate. However, the genetic diversity of this gene might influence performance of RDT kits and its drug target candidacy. This study aimed to determine polymorphism of pLDH gene from Iranian isolates of P. vivax and P. falciparum. METH...
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The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90% identity to PfLDH, it would be desirable to have new anti-pLDH drugs, particularly ones that are effe...
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Background : Lactate dehydrogenase (LDH) activity was assayed in the sera of 40 adult male and 40 adult female patients within the age group of 16-50 years presenting with acute, Plasmodium falciparum malaria infection and a control group of 40 healthy adults within the same age group. Study objective: Study was design to determine diagnostic value of serum LDH activity in patient with acute P....
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OBJECTIVES Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve malaria elimination/eradication. We developed a novel colorimetric screening method for anti-gametocyte compounds based on the parasite lactate dehydrogenase (pLDH) assay, already standardized for asexual stages, to measure ...
متن کاملDetection of histidine rich protein & lactate dehydrogenase of Plasmodium falciparum in malaria patients by sandwich ELISA using in-house reagents
BACKGROUND & OBJECTIVES Despite major control efforts, malaria remains a major public health problem that still causes high mortality rate worldwide especially in Africa and Asia. Accurate and confirmatory diagnosis before treatment initiation is the only way to control the disease. The present study was undertaken to develop reagents using sandwich ELISA for simultaneous detection of PfHRP2 (P...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 1997
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/10.1.39